Figure 2 | Scientific Reports

Figure 2

From: A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation

Figure 2

Meta-analysis of the overall effect of NOX2 on infarct size and neurological score in experimental stroke.

Studies included are shown on the left and analyzed in two forest plots, either without (left section) or with (right section) the data of the here presented randomized, confirmatory, blinded study. Subgroups within one study are depicted separately with the following coding: a, female gender; b, male gender; c, short ischemic time; d, medium ischemic time; e, long ischemic time. The upper half a, contains data for the effect of NOX2 on infarct size (IS); the lower half b, on neurological score (NS). Displayed are the standardized mean difference (SMD), 95% confidence intervals and relative weight of the individual studies. The diamond indicates the global SMD and its 95% confidence interval.

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