Figure 2 | Scientific Reports

Figure 2

From: Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease

Figure 2

Expression of FGF19 and FGFR4 in liver tissue of patients with PBC.

(A) FGF19 mRNA expression was significantly enhanced both in non-cirrhotic (n = 24) and cirrhotic (n = 21) PBC livers. (B) Expression of liver FGF19 mRNA in non-cirrhotic patients increased along with the stage of fibrosis. Levels of mRNA expression were normalized with glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and presented as a fold-change relative to control. Bars indicate the mean ± SEM. In cirrhotic liver (n = 21) protein levels of (C) FGF19 and (D) FGFR4 were substantially increased when compared to control tissue (n = 21). Changes in protein levels were determined by densitometry analyses after normalization to α/β tubulin as a control for loading. Data presented as the box-and-whisker plot with median value (middle line).

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