Figure 1 | Scientific Reports

Figure 1

From: HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal cell carcinoma

Figure 1

Correlation between HCRP-1 expression and clinicopathologic parameters in RCC.

(A) Representative immunohistochemical photographs were taken at different magnifications in tumor adjacent normal renal tissue and renal carcinoma tissues (Top panel ×100, bottom panel ×400). (B) Compared with that in the tumor adjacent normal renal tissue, the overall expression level of HCRP-1 in the renal cell carcinoma tissues was significantly lower (P < 0.01, χ2 test). (C) Decreased HCRP-1 expression was correlated with histological grade (P < 0.005, χ2 test, comparing I-II versus III-IV). (D) Decreased HCRP-1 expression was correlated with TNM stage (P < 0.005, χ2 test, comparing I-II versus III-IV). (E) Decreased HCRP-1 expression was correlated with depth of invasion (P < 0.005, χ2 test, comparing pT1 versus pT2–pT3).

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