Figure 5 | Scientific Reports

Figure 5

From: Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting

Figure 5

Mechanism of action of Amodiaquine.

AQ reduces the activities of pathogens that enter into host cytoplasm from acidified endosomes by exploiting cellular cathepsin B. AQ does not inhibit the entry of pathogens that enter through a retrograde fashion to the endoplasmic reticulum (ER) and retrotranslocated into the cytoplasm by the host ER-associated degradation pathway or by pH-independent entry into cytoplasm.

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