Table 1 The effect of AQ, CQ and its metabolites, DEAQ and DECQ, on the pathogenicity of EBOV in HeLa cells.

From: Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting

Pathogen

Drug, hours

EC50

SD

CC50

SI50

μM

μM

μM

EBOV

AQ, 48 h

3.8

0.38

50

13.2

EBOV

DEAQ, 48 h

3.6

0.35

50

13.9

EBOV

CQ, 48 h

4.8

0.57

100

20.7

EBOV

DECQ, 48 h

7.3

0.55

100

13.8

  1. The ability of drugs to reduce the abundance of Ebola virus (EBOV) in host cells was measured in cells by fluorescent microscopy.
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