Table 2 Logistic regression analysis for the associations of the FAM13A SNPs with COPD and LC.

From: Susceptibility loci in lung cancer and COPD: association of IREB2 and FAM13A with pulmonary diseases

SNP

Frequency of genotypes

OR (95% CI)

P

Frequency of genotypes

OR (95% CI)

P

Frequency of genotypes

OR (95% CI)

P

Controls

COPD

LC

COPD with LC+COPD

rs7671167

 TT

0.24

0.38

11

 

0.28

11

 

0.35

11

 

 TC

0.50

0.47

0.62 [0.41–0.93]

0.0223

0.44

0.79 [0.58–1.06]

0.118

0.49

0.69 [0.49–0.98]

0.036

 CC

0.26

0.15

0.19 [0.09 –0.37]

<0.0001 2

0.28

0.95 [0.67–1.34]

0.761

0.16

0.45 [0.29–0.70]

0.0004 2

 TC+CC

0.76

0.62

0.54 [0.36–0.79]

0.0015 2

0.72

0.84 [0.63–1.12]

0.230

0.65

0.61 [0.44–0.85]

0.003 2

rs1903003

 TT

0.27

0.40

11

 

0.32

11

 

0.38

11

 

 CT

0.51

0.47

0.63 [0.42–0.94]

0.024

0.46

0.77 [0.58 –1.04]

0.084

0.49

0.69 [0.49–0.96]

0.028

 CC

0.22

0.13

0.41 [0.23–0.71]

0.0014 2

0.22

0.85 [0.60–1.20]

0.355

0.13

0.42 [0.26–0.67]

0.0002 2

 CT+CC

0.73

0.60

0.56 [0.38–0.52]

0.0028 2

0.68

0.80 [0.61 –1.05]

0.103

0.62

0.60 [0.44–0.83]

0.0019 2

rs2869967

 TT

0.34

0.23

11

 

0.35

11

 

0.23

11

 

 CT

0.49

0.49

1.41 [0.90–2.20]

0.134

0.43

0.86 [0.65–1.14]

0.295

0.49

1.44 [0.48–1.00]

0.052

 CC

0.17

0.28

2.41 [1.44–4.05]

0.0007 2

0.22

1.27 [0.89–1.81]

0.193

0.28

2.36 [1.53–3.64]

<0.0001 2

 CT+CC

0.66

0.77

1.66 [1.09–2.53]

0.0170 2

0.65

0.96 [0.74–1.25]

0.782

0.77

1.67 [1.18–2.36]

0.0034 2

  1. COPD—chronic obstructive pulmonary disease; LC—lung cancer; COPD with LC+COPD: the associations with COPD were studied twice: using pure COPD group and COPD with 40% admixture of subjects with concomitant LC.
  2. 1Reference category; OR (95% CI), odds ratio (95% confidence interval).
  3. 2Result statistically significant (P < 0.0125, after Bonferroni correction).
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