Figure 3 | Scientific Reports

Figure 3

From: Synthesis of Structurally Diverse 2,3-Fused Indoles via Microwave-Assisted AgSbF6-Catalysed Intramolecular Difunctionalization of o-Alkynylanilines

Figure 3

Synthesis of indoles fused to saturated medium-sized N-containing rings by means of intramolecular difunctionalization[a].

[a]The yields given are isolated yields. DCE = 1,2-dichloroethane, MW = microwave. [b]Method A: The reaction was conducted with 1 (1 equiv) and 2 (2 equiv) in the presence of AgSbF6 (10 mol%) at a MW power of 100 W in DCE for 6 h at 80 °C. [c]Method B: The reaction was conducted with 1 (1 equiv) in the presence of AgSbF6 (10 mol%) at a MW power of 100 W in DCE for 3 h at 80 °C. Then 2 (2 equiv) was added and the mixture was allowed to react under the same conditions for another 3 h. [d]Method C: Similar to method B, except that CF3COOH (1.5 equiv) was added along with 2 (2 equiv) in the second step.

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