Table 1 Study characteristics from included studies in the meta-analysis.

From: The nitric oxide synthase 3 G894T polymorphism associated with Alzheimer’s disease risk: a meta-analysis

First author	Year	Country	Ethnicity	Cases				Controls			Criteria for AD diagnosis	Time of AD onset	Control type	Quality score
First author	Year	Country	Ethnicity	N^a	Age^b	Age^c	Gender^d	N	Age^b	Gender^d	Criteria for AD diagnosis	Time of AD onset	Control type	Quality score
Dahiyat M -1	1999	UK	Caucasian	260	57.0	79.8	35.6	207	71.0	47.1	NINCDS/ADRDA	Mixed	PB	10
Dahiyat M -2	1999	UK	Caucasian	179	74.0	82.0	51.4	186	77.0	50.0	NINCDS/ADRDA	Late	PB	10
Crawford F	2000	USA	Caucasian	287	73.0	—	33.0	120	73.3	42.0	NINCDS/ADRDA	Late	PB	8
Higuchi S	2000	Japan	Asian	411	—	76.0	27.3	350	75.7	27.7	NINCDS/ADRDA	Mixed	PB	10
Kunugi H	2000	Japan	Asian	172	—	74.1	34.3	165	57.0	41.2	NINCDS/ADRDA	Mixed	HB	6
Emahazion T	2001	Scotland	Caucasian	121	—	—	—	152	—	—	NINCDS/ADRDA	Early	PB	11
Sanchez-Guerra M	2001	Spain	Caucasian	301	71.5	75.2	34.0	309	80.3	29.0	NINCDS/ADRDA	Mixed	HB	7
Singleton A	2001	UK	Caucasian	212	79.8	—	33.3	106	78.2	47.6	NINCDS/ADRDA	Late	PB	9
Tedde A	2002	Italy	Caucasian	220	65.0	—	36.4	95	80.8	42.1	DSM-IV	Mixed	PB	9
Kalman J	2003	Hungary	Caucasian	51	—	76.0	31.4	51	72.0	47.1	NINCDS/ADRDA DSM-III	Late	PB	7
Monastero R	2003	Italy	Caucasian	149	69.7	72.0	38.5	149	73.3	38.5	NINCDS/ADRDA	Mixed	PB	10
Yang Z	2004	China	Asian	68	72.8	—	38.2	158	71.2	50.0	NINCDS/ADRDA DSM-III	Late	PB	11
Blomqvist ME	2005	Sweden	Caucasian	382	76.2	—	37.1	170	73.2	46.7	NINCDS/ADRDA	Mixed	HB	7
Guidi I	2005	Italy	Caucasian	405	73.0	—	29.6	253	71.0	42.3	NINCDS/ADRDA	Mixed	HB	8
Akomolafe A -1	2006	USA	Caucasian	235	—	71.4	24.0	82	72.3	30.0	NINCDS/ADRDA	Mixed	PB	13
Akomolafe A -2	2006	Mixed^e	Caucasian	259	—	68.3	34.0	127	71.7	59.0	NINCDS/ADRDA	Mixed	PB	10
Zhou Y	2006	China	Asian	530	—	71.3	63.0	601	71.5	55.9	NINCDS/ADRDA DSM-IV	Mixed	PB	9
Li H	2008	Canada	Caucasian	688	77.8	71.9	42.4	681	73.4	35.6	NINCDS/ADRDA	Mixed	PB	15
Styczynska M	2008	Poland	Caucasian	154	—	71.5	33.8	176	72.7	31.8	NINCDS/ADRDA	Late	PB	11
Wang B	2008	China	Asian	338	77.6	—	51.0	378	72.9	58.0	NINCDS/ADRDA DSM-III	Late	PB	11
Giedraitis V	2009	Sweden	Caucasian	79	—	80.2	100	361	81.8	100	NINCDS/ADRDA DSM- IV	Late	PB	10
Azizi Z	2010	Iran	Asian	100	73.8	—	44.0	100	72.6	48.0	NINCDS/ADRDA	Late	PB	9
Ferlazzo N	2011	Italy	Caucasian	69	77.2		42.0	69	75.6	34.8	NINCDS/ADRDA	Early	PB	10

DSM: the Diagnostic and Statistical Manual of Mental Disorders; NINCDS: the National Institute of Neurological Disorders and Stoke; ADRDA: Alzheimer Diseases and Related Disorders Association; MMSE: mini-mental state examination; NA: not applicable; SNP: Single Nucleotide Polymorphism; PB = population based control; HB = hospital based control.
^aNumber.
^bage at survey.
^cage at onset of Alzheimer’s disease.
^dpercentage of male.
^eparticipants from four countries (Canada, Germany and Greece).

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Table 1 Study characteristics from included studies in the meta-analysis.

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