Table 3 Total, stratified and sensitivity analysis of NOS3 G894T polymorphism and the AD susceptibility.
Summary | Na | Cases/Controls | Q Test | I2,% | Odds Ratio | 95% Confidence Interval | P for Z testc | P for interactiond | ||
|---|---|---|---|---|---|---|---|---|---|---|
χ2 | df | P Valueb | ||||||||
All studies | 23 | 5,670/5,046 | 44.07 | 22 | 0.003 | 50.1 | 1.18 | 1.04, 1.35 | 0.010 | - |
Subgroup analysis | ||||||||||
Time of AD onset | 0.049 | |||||||||
Early | 8 | 706/1,525 | 4.17 | 7 | 0.760 | 0.0 | 1.02 | 0.83, 1.26 | 0.834 | |
Late | 14 | 2,568/2,866 | 37.63 | 13 | <0.001 | 65.5 | 1.33 | 1.07, 1.66 | 0.010 | |
Ethnic descent | 0.246 | |||||||||
Caucasiane | 17 | 4,051/3,294 | 35.04 | 16 | 0.004 | 54.3 | 1.15 | 0.99, 1.34 | 0.075 | |
Asian | 6 | 1,619/1,752 | 7.68 | 5 | 0.175 | 34.9 | 1.31 | 1.03, 1.67 | 0.030 | |
APOE | 0.925 | |||||||||
ε4+ | 5 | 347/161 | 5.74 | 4 | 0.220 | 30.3 | 1.25 | 0.82, 1.91 | 0.304 | |
ε4- | 5 | 560/884 | 9.74 | 4 | 0.045 | 58.9 | 1.22 | 0.95, 1.56 | 0.116 | |
HWE in controls | 0.065 | |||||||||
Yes | 18 | 4,580/3,938 | 29.16 | 17 | 0.033 | 41.7 | 1.12 | 1.02, 1.23 | 0.021 | |
No | 5 | 1,090/1,108 | 11.51 | 4 | 0.021 | 65.3 | 1.48 | 1.04, 2.12 | 0.030 | |
Control type | 0.912 | |||||||||
PB | 19 | 4,410/4,149 | 36.99 | 18 | 0.005 | 51.3 | 1.20 | 1.03, 1.39 | 0.018 | |
HB | 4 | 1,260/897 | 7.07 | 3 | 0.070 | 57.5 | 1.15 | 0.85, 1.54 | 0.367 | |
Date of publication | 0.139 | |||||||||
≤2003 | 11 | 2,363/1,890 | 21.51 | 10 | 0.018 | 53.5 | 1.09 | 0.90, 1.34 | 0.380 | |
>2003 | 12 | 3,307/3,156 | 20.37 | 11 | 0.040 | 46.0 | 1.27 | 1.08, 1.50 | 0.005 | |
Quality score | 0.599 | |||||||||
Low | 10 | 2,660/1,970 | 20.04 | 9 | 0.018 | 55.1 | 1.16 | 0.94, 1.43 | 0.158 | |
High | 13 | 3,010/3,076 | 23.75 | 12 | 0.022 | 49.5 | 1.21 | 1.02, 1.43 | 0.031 | |
Sensitivity analyses | — | |||||||||
Minimal | 22 | −/− | 38.46 | 21 | 0.011 | 45.4 | 1.16 | 1.02, 1.31 | 0.025 | |
Maximal | 22 | −/− | 39.82 | 21 | 0.008 | 47.3 | 1.21 | 1.06, 1.38 | 0.004 | |
