Figure 1 | Scientific Reports

Figure 1

From: Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy

Figure 1

(A) Mean change in body weight of mice up to five weeks after adriamycin administration. Animals of the ADR group had a mean body weight loss of approximately 20% by week 1, while control animals had a mean body weight gain of 5%. (B) Mean albuminuria over 24 hours, measured weekly. ADR-administered animals had a mean maximum of albuminuria of approximately 90 mg/24 h at 3 weeks, while in control animals urinary albumin stayed constant throughout the study at around 0.03 mg/24 h. (C) Mean albumin:creatinine ratio (alb:cr) measured weekly, showing similar temporal dynamics to 24 h albuminuria. Data points (circles = control, n = 5; squares = ADR-administered, n = 6) and bars show mean ± standard error. Asterisks indicate significance of mixed-design ANOVA models: p ≤ 0.01 (**), p ≤ 0.001 (***), see also Table S3.

Back to article page