Figure 3 | Scientific Reports

Figure 3

From: Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy

Figure 3

(A) MSOT images of a typical control (top) and ADR-administered (bottom) mouse before and after the administration of IRDye. Region of interests (ROIs) depicted in yellow (cortex) and red (papilla/pelvis region). Times indicated above apply to both control and ADR-treated animal. (B) Temporal colour maps of control and ADR-administered mice reveal a delay in IRDye clearance kinetics in the treated mice. (C) Characteristic plot of mean pixel intensity (MSOT arbitrary units) from ROIs drawn around the renal cortex (black) and papilla/pelvis region (grey). (D,E) Graphs showing distribution of TMAX delay (D) and the excretion half-life in the cortex (E) in ADR-administered and control animals. Data points (D,E) represent individual animals (circles = control, n = 5; squares = ADR-administered, n = 6) and lines represent mean ± standard error. Asterisks indicate significance of two-sample t-tests: p ≤ 0.05 (*), see also Table S2.

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