Figure 5

Replication kinetic of a representative outbreak-associated isolate XY1 relative to non-outbreak-associated isolate CDC228.
Since the outbreak isolates shared an indistinguishable genome content, a representative outbreak-associated isolate XY1 was used to evaluate the viral replication. The isolate XY1 was recovered from the first case (Index case A) from the Xiangyang outbreak and the on-outbreak-associated isolate CDC228 was recovered from a sporadic ARD patient from Xiangyang City. Virus titers were determined in Hep-2 cells by measuring the 50% tissue culture infectious dose (TCID50).