Figure 5
From: Rapid, high efficiency isolation of pancreatic ß-cells
Gene expression profiling of ß-cells at different ages and stages of diabetes development.
(a) Transcriptional profiling data depicting genes that were increased >2 fold in ß-cells from 12 week old mice (red) and genes that were increased >2 fold in ß-cells from 4 week old mice (blue). (b) Gene ontology analysis of GO terms arising from genes up-regulated >2 fold at 4 weeks of age. (c) Gene ontology analysis of GO terms arising from genes up-regulated >2 fold at 12 weeks of age. (d) IFN alpha and (e) IFN gamma induced gene transcripts highlighted on a volcano plots (p-value vs. fold change) depicting up-regulated (right quadrant) and down-regulated (left quadrant) gene expression in ß-cells isolated from 12 week old mice compared to 4 week old mice. P-Values were determined using a chi-square test.
