Figure 1

Mechanism of Ac-SDKP fragments binding to N-domain ACE.

(A) Portions of the electron density map at the site of the bound peptides with left, Ac-SD and right, KP. The maps were generated using REFMAC5⁶¹ and correspond to the difference weighted 2mFo-DFc density map, contoured at 1.0σ level, in which the peptide atoms were omitted. N-dom in cyan (interacting residues in stick representation), bound dipeptides in grey stick, catalytic zinc ion and water molecules as grey and red spheres respectively. (B) Schematic of peptide binding to N-ACE. Interactions were calculated with LigPlot⁺⁶⁴. (C) Superposition of the dipeptide Ac-SD and KP structures. Ac-SD and KP are presented in black and grey sticks, respectively.