Figure 4
From: Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme
Comparison of domain specific substrate and inhibitors in ACE.
(A) Model of Ac-SDKP binding to N-domain ACE (as above). The catalytic channel is represented with a transparent surface calculated with the program HOLLOW66 (B) Model of Ac-SDKP binding to C-domain ACE, with C-domain ACE in blue and Ac-SDKP in purple. (C) Crystal structure of the N-domain specific RXP 407 inhibitor bound to N-domain ACE (PDB 3NXQ)30, with RXP 407 in pink. (D) Crystal structure of C-domain ACE in complex with AngII (PDB 4APH)31; with AngII in yellow. Non-conserved residues of the catalytic channel are indicated by a framed label. The residues involved in N-domain specificity30 are labelled in red.
