Figure 5
From: Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme
Proposed model for the catalytic mechanism of Ac-SDKP hydrolysis by N-domain ACE.
(A) Model of Ac-SDKP (grey) bound to N-domain ACE (cyan) prepared as above. N-domain ACE residues involved in the zinc-mediated activity and stabilisation of the potential transition state intermediates are shown as stick. The water involved in the nucleophilic reaction is shown in red (sphere). (B) Potential role of the chloride ion in activity. Chloride ion is shown in green, with potential hydrogen bond and water mediated-interactions with the catalytic site highlighted as green dashes.
