Table 3 The HRs of incident HU across the quartiles of Hct.
Quartile of baseline Hct | P for trend | ||||
|---|---|---|---|---|---|
1(lowest) | 2 | 3 | 4(highest) | ||
Minimum follow-up = 1 year (62897 person-years) | |||||
Median (range) | 35.5(<37.4) | 38.8(37.4–40.3) | 42.0(40.4–43.7) | 45.7(>43.7) | – |
No. of subjects | 6908 | 6936 | 6899 | 6797 | – |
Person-years of follow-up | 16815 | 16028 | 15856.5 | 14197.5 | – |
Incidence of HU (per 1000 person-years) | 22.8 | 33.6 | 50.8 | 71.7 | – |
Unadjusted HR (95%CI) | 1.00(reference) | 1.46(1.28, 1.67) | 2.21(1.96, 2.50) | 3.09(2.74, 3.47) | 0.00 |
P value | – | 0.00 | 0.00 | 0.00 | – |
Age, sex, BMI adjusted HR (95%CI) | 1.00(reference) | 1.16(1.01, 1.33) | 1.20(1.04, 1.39) | 1.44(1.24, 1.68) | 0.00 |
P value | – | 0.03 | 0.02 | 0.00 | – |
Multivariable adjusted HR (95%CI) | 1.00(reference) | 1.10(0.96, 1.26) | 1.08(0.93, 1.25) | 1.20(1.03, 1.41) | 0.02 |
P value | – | 0.18 | 0.34 | 0.02 | – |
Minimum follow-up = 2 years (60418 person-years) | |||||
Multivariable adjusted HR (95%CI) | 1.00(reference) | 1.10(0.96, 1.26) | 1.09(0.94, 1.26) | 1.23(1.05, 1.44) | 0.01 |
P value | – | 1.77 | 0.26 | 0.01 | – |
Minimum follow-up = 3 years (48818 person-years) | |||||
Multivariable adjusted HR (95%CI) | 1.00(reference) | 1.12(0.98, 1.28) | 1.13(0.97, 1.32) | 1.30(1.11, 1.52) | 0.00 |
P value | – | 0.10 | 0.11 | 0.00 | |
Minimum follow-up = 4 years (37378 person-years) | |||||
Multivariable adjusted HR (95%CI) | 1.00(reference) | 1.27(1.11, 1.46) | 1.38(1.18, 1.61) | 1.70(1.44, 2.00) | 0.00 |
P value | – | 0.00 | 0.00 | 0.00 | – |
