Figure 3 | Scientific Reports

Figure 3

From: Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism

Figure 3

Simvastatin does not impair PPAR-γ mediated glucose uptake: Mean basal and insulin stimulated (5 min and 10 min) uptake of 2-NBDG by L6 myotubes treated with Simvastatin (1 μM) and/or Pioglitazone (10 μM) for different time points as indicated. DMSO (0.1%) treated cells served as internal control. Values are shown as mean±SD after normalizing with the corresponding protein content and expressed relative to basal of control cells which was set to 1; *p < 0.05, **p < 0.01, versus corresponding control cells , bp < 0.005 versus corresponding Simvastatin treated cells (two way ANOVA).

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