Table 4 Association between genotypes of rs10889677 and clinical characteristics among gout patients.

From: Associations between interleukin and interleukin receptor gene polymorphisms and risk of gout

rs10889677 n

(1) AA n

(2) AC n

(3) CC n

(1) vs.

(1) + (2)

(1) vs.

(2) vs.

vs. (3)

(2) + (3)

(3)

1100

578

517

5

P

P

P

Clinical and serum biochemical indexes (mean ± SD)

 Age of onset

44.57 ± 13.51

45.69 ± 13.53

49.80 ± 13.99

0.309

0.663

0.169

 BMI (kg/m2)

26.35 ± 5.65

25.80 ± 6.30

27.06 ± 3.29

0.309

0.534

0.144

 Systolic pressure (mmHg)

135.87 ± 19.50

134.90 ± 19.12

148.50 ± 34.30

0.297

0.281

0.488

 Diastolic pressure (mmHg)

88.09 ± 11.94

87.98 ± 12.92

94.25 ± 23.21

0.604

0.435

0.948

 Blood glucose (mmol/L)

6.13 ± 2.45

6.19 ± 1.73

5.61 ± 0.40

0.783

0.424

0.719

 Uric acid (μmol/L)

470.65 ± 120.93

476.00 ± 123.60

453.33 ± 180.94

0.593

0.795

0.490

 Triglycerides (mmol/L)

2.33 ± 1.58

2.40 ± 1.94

1.74 ± 1.41

0.393

0.351

0.551

 Total cholesterol (mmol/L)

5.16 ± 1.21

5.24 ± 1.19

5.58 ± 0.16

0.345

0.776

0.226

 Creatinine (μmol/L)

86.23 ± 30.19

89.39 ± 39.93

89.20 ± 8.61

0.724

0.939

0.149

Clinical data (n(%))

 Tophi

102/578

113/517

1/5

0.169*

0.999*

0.104

 Hypertensiona

196/578

214/517

3/5

0.020*

0.370

0.009

 Diabetesb

45/578

39/517

0/5

0.939*

0.999*

0.845

 Obesityc

213/578

165/517

1/5

0.187*

0.665

0.078

  1. BMI: body mass index.
  2. *P-value of Fisher’s exact test.
  3. aHypertension: systolic pressure ≥140 mmHg or diastolic pressure ≥90 mmHg or having a previous history of hypertension and receiving anti-hypertensive medication.
  4. bDiabetes: fasting blood glucose ≥7.0 mmol/L (126 mg/dL) or random blood glucose ≥11.1 mmol/L (200 mg/dL) or under treatment.
  5. cObesity: BMI ≥ 28 kg/m2.
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