Figure 4

Comparative in vivo activities for Artemether (ATM), Lumefantrine (LUM) and NVP-BGT226 as single agents and in combination.

P. berghei infected BALB/c mice were treated with ATM (5 mg/kg), LUM (5 mg/kg), NVP-BGT226 (4 mg/kg), or NVP-BGT226 (8 mg/kg), or combinations thereof as indicated above. (A) Parasitemia values for ATM, LUM and NVP-BGT226 as either single agents or in combination. All treatment was started three days post infection, with doses administered by oral gavage on day 3, 4 and 5 (3 doses) or on days 3 and 4 (2 doses). (B) Survival plot for ATM, LUM and NVP-BGT226 as either single agents or in combination. All mice that survived until day 30 (5/5- ATM/LUM (3 doses); 5/5- LUM/NVP-BGT226 (3 doses); 2/5- ATM/NVP-BGT226 (2 doses); 5/5- LUM/NVP-BGT226 (2 doses)) remained negative for parasites through 60 day post infection follow-up.