Table 2 Comparative analysis of combination responses in Dd2 as judged by single point Chou-Talalay analysis for selected drug combinations at IC₅₀ and LD₅₀ concentrations (n = 3, +/− SEM values provided in SI) and at the anticipated in vivo concentration (AIVC). Values for HB3 are provided in table S8.

Drug Combination	Avg. FIC		Avg. FIC_Index	Avg. FLD		Avg. FLD_Index	Avg. FAIVC^a		Avg. FAIVC_Index
Drug Combination	Drug A	Drug B	Avg. FIC_Index	Drug A	Drug B	Avg. FLD_Index	Drug A	Drug B	Avg. FAIVC_Index
ATM + LUM	0.67	0.47	1.1 (Add.)	0.42	0.58	1.0 (Syn.)	ND	ND	ND
ATM + GSK-2126458	0.54	0.52	1.1 (Add.)	0.18	0.21	0.39 (Syn.)	ND	ND	ND
ATM + NVP-BGT226	0.97	1.05	2.0 (Add.)	0.27	0.46	0.93 (Syn.)	0.85	0.14	0.99 (Syn.)
ATM + Torin 2	0.75	0.59	1.3 (Add.)	0.54	0.60	0.94 (Syn.)	ND	ND	ND
LUM + GSK-2126458	0.27	0.40	0.67 (Syn.)	0.20	0.15	0.35 (Syn.)	ND	ND	ND
LUM + NVP-BGT226	0.60	0.93	1.5 (Add.)	1.10	1.17	2.0 (Ant.)	0.45	0.05	0.49 (Syn.)
LUM + Torin 2	0.44	0.48	0.9 (Syn.)	0.50	0.19	0.5 (Syn.)	ND	ND	ND

^aData indicates a ratio of ATM:NVP-BGT226 of 100:1 and a ratio of LUM:NVP-BGT226 of 500:1. Additional ratios for ATM:NVP-BGT226 include 50:1, 200:1 and 400:1 and for LUM:NVP-BGT226 include 250:1, 1250:1 and 25000:1. These data are presented in table S8. FIC (fractional inhibitory concentration); FLD (fractional lethal dose); FAIVC (fractional anticipated in vivo concentration); ATM (artemether); LUM (lumefantrine); Add. (additive); Syn. (synergistic); Ant. (antagonistic).

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