Figure 1
From: IP3R deficit underlies loss of salivary fluid secretion in Sjögren’s Syndrome
Morphology of minor salivary glands from healthy volunteers (HV) and primary Sjögren’s patients (pSS).
Samples from (HV) and pSS patients with focus scores (FS) of 1, 3 and 5 were stained with hematoxolin and eosin. Morphology was assessed using 20× objectives. (A–D show larger areas of the tissue sample while enlarged areas of the portions marked are shown in (a–d). Relatively intact morphologically normal looking areas in the sections are shown by black arrows, while infiltrated areas are indicated by red arrows. Samples from pSS patient with FS = 5 (D, d) displays diffused infiltration with little residual gland morphology (E) Displaying whole unstimulated salivary flow measured in individual HV (N = 22) and pSS FS = 1 patients (N = 11). Mean ± SEM for the HV group is 5.827 ± 0.8556 ml/15 min and for the pSS group, 1.759 ± 0.4334 ml/15 mins (* denotes a significant difference between Means, p < 0.0001). (A–D, scale bar = 100 microns) (a–d, scale bar = 50 microns).
