Figure 2
From: IP3R deficit underlies loss of salivary fluid secretion in Sjögren’s Syndrome
Carbachol-stimulated decrease in acinar cell volume is attenuated in minor salivary gland biopsies from pSS patients.
(A) Calcein fluorescence was monitored in acinar cells using confocal microscopy. The data in A were used to quantitate: (B) Decrease in volume in HV (20.61017 F/F0 ± 1.29369) vs in the pSS patients (10.4703 F/F0 ± 0.94543) (C) Initial rate of volume decrease in HV and pSS cells (0.1861 F/F0/Sec ± 0.01837 in the HV versus 0.09333 F/F0/Sec ± 0.006863 in the pSS individuals (p < 0.0001). (D) Spearman r correlation between CCh-stimulated volume decrease and salivary flow in the pSS patients (red symbols) and HV (black symbols) (p = 0.0323, eleven HV and thirteen pSS). (E) Spread of CCh-stimulate volume changes in individual patients from HV and pSS groups (p = 0.0010). * indicates significant difference.
