Figure 6
From: IP3R deficit underlies loss of salivary fluid secretion in Sjögren’s Syndrome
Ca2+ Signaling in lobules from IL14 alpha transgenic mice.
(A) Representative traces from female, age matched wild type controls showing the concentration-dependent change in [Ca2+]i stimulated by a range of [CCh] in submandibular acini. The traces represent the normalized change in fluorescence for an individual cell within an acinus. Cells from different acini in the field of view in one lobule are presented. Experiments were performed on at least 9 lobules from 3 different animals. (B) [Ca2+] signals are significantly reduced in IL14α animals. (C) Pooled data. [Ca2+] signals are significantly reduced in response to sub-maximal [CCh] *p = <0.01.
