Figure 7
From: IP3R deficit underlies loss of salivary fluid secretion in Sjögren’s Syndrome
IP3R2 expression in submandibular salivary glands from female IL14 alpha transgenic mice.
(A) Left panel shows the typical apical staining of IP3R2 in age matched control animals. Middle panel show the basal localization of the Na/K-ATPase. Right panel overlay of IP3R2 and Na/K-ATPase localization. (B) Left panel shows the typical apical staining of IP3R2 in male 10 month old IL14a animals. Middle panel show the basal localization of the Na/K-ATPase. Right panel overlay of IP3R2 and Na/K-ATPase localization. (C) Left panel shows the absence of typical apical staining of IP3R2 in female 10 month old IL14a animals. Middle panel show the basal localization of the Na/K-ATPase. Right panel overlay of IP3R2 and Na/K-ATPase localization. (scale bar = 10 microns).
