Table 2 Comparison of histological scores and NASH between the study groups.
Item | Category | Control group (n = 6) | HFHSD group (n = 6) |
|---|---|---|---|
Steatosis | |||
Grade | 0 (0–4%) | 4* | 0 |
1 (5%–33%) | 2 | 1 | |
2 (34%–66%) | 0 | 3 | |
3 (67%–100%) | 0 | 2 | |
Location | Zone 3 | 0 | 1 |
Zone 1 | 0 | 3 | |
Azonal | 0 | 2 | |
Type | Macro-vacuolar | 0 | 1 |
Micro-vesicular | 2 | 5 | |
Inflammation | |||
Lobular inflammation | 0 (no foci) | 0 | 0 |
1 (<2 foci) | All minipigs | 0 | |
2 (2–4 foci) | 0 | 4 | |
3 (>4 foci) | 0 | 2 | |
Portal inflammation | 0 | All minipigs | |
Hepatic glycogen | |||
Location | None | 5 | 0 |
Zone 3 | 0 | 4 | |
Zone 1 | 1 | 2 | |
NAS | |||
0–2 | 6 | 1 | |
3–4 | 0 | 4 | |
5–8 | 0 | 1 | |
