Table 2 Association between SNPs in autophagy pathway and BCR in localized prostate cancer patients treated with RP.
From: Genetic variants of the autophagy pathway as prognostic indicators for prostate cancer
Gene SNP Genotype | Patients, n | Events, n | Median, mo | HR (95% CI) a | P a | q |
|---|---|---|---|---|---|---|
ATG16L1 rs78835907 | ||||||
GG | 184 (41.7) | 81 (45.8) | 71 | 1.00 | ||
GA | 214 (48.5) | 85 (48.0) | 76 | 0.71 (0.51–0.98) | 0.035 | |
AA | 43 (9.8) | 11 (6.2) | 85 | 0.47 (0.24–0.91) | 0.024 | |
GA/AA vs GG | 0.67 (0.49–0.91) | 0.012 | 0.087 | |||
AA vs GG/GA | 0.56 (0.30–1.07) | 0.082 | 0.167 | |||
Trend | 0.70 (0.54–0.90) | 0.006 | 0.054 | |||
ATG16L1 rs13021297 | ||||||
GG | 214 (47.1) | 72 (40.0) | 121 | 1.00 | ||
GA | 196 (43.2) | 86 (47.8) | 71 | 1.59 (1.14–2.21) | 0.006 | |
AA | 44 (9.7) | 22 (12.2) | 53 | 1.71 (1.03–2.84) | 0.039 | |
GA/AA vs GG | 1.61 (1.17–2.21) | 0.003 | 0.054 | |||
AA vs GG/GA | 1.35 (0.84–2.16) | 0.216 | 0.221 | |||
Trend | 1.38 (1.10–1.72) | 0.005 | 0.054 | |||
MAP1LC3B rs8044820 | ||||||
AA | 242 (54.5) | 97 (54.8) | 82 | 1.00 | ||
AG | 175 (39.4) | 65 (36.7) | 97 | 1.00 (0.73–1.39) | 0.985 | |
GG | 27 (6.1) | 15 (8.5) | 35 | 2.33 (1.31–4.16) | 0.004 | |
AG/GG vs AA | 1.12 (0.82–1.52) | 0.473 | 0.245 | |||
GG vs AA/AG | 2.33 (1.33–4.09) | 0.003 | 0.054 | |||
Trend | 1.24 (0.96–1.61) | 0.101 | 0.167 | |||
