Figure 2
From: Deleterious Germline BLM Mutations and the Risk for Early-onset Colorectal Cancer
Loss of heterozygosity analyses of the deleterious BLM mutation in the tumour of P034.
(a) Sanger sequencing results of the region around the variants in reference DNA, DNA from normal- and tumour tissue from the patient, showing a loss of the wild-type C-allele in the tumour. (b) B-allele frequency plot of chromosome 15 showing the loss of heterozygosity along the entire chromosome 15 in the tumour of individual P034 (top) as compared to a reference (bottom). A blue arrow on the top ideogram marks the BLM locus.
