Figure 7

GPR120 improves the bone mass and bone structure of ovariectomized mice.

Groups: a: Sham; b: OVX; c: OVX + TUG-891 (0.1 mg/kg); d: OVX + TUG-891 (1 mg/kg); e: OVX + TUG-891 (5 mg/kg); f: OVX + TUG-891 (10 mg/kg); g: OVX + TUG-891 (30 mg/kg); h: OVX + TUG-891 (50 mg/kg). (A,B) Analysis of micro-CT in the distal metaphyseal femur region. (C) Van Gieson (VG) staining of the distal femur. The figure was 40 × and 100 × of the original section. (D) Procedure for the in vivo injection of TUG-891 among the different groups. (E,K) Analysis of micro-CT quantification in the distal metaphyseal femur region. The following 3D indices in the defined region of interest (ROI) were analysed: BMD, Conn.D, SMI, Tb.N, Tb.Th, Tb.Sp and BV/TV. *P < 0.05 and **P < 0.01 compared with the sham group. ^#P < 0.05 and ^##P < 0.01 compared with the OVX group.