Figure 1
From: Imbalance between the expression dosages of X-chromosome and autosomal genes in mammalian oocytes
Identification of differentially expressed genes during oogenesis in mice.
(a) Venn diagram showing the total number of differentially expressed genes based on TMM normalization values. Significant differences in FGO- and NGO-specific genes (3016 and 2853 genes, respectively) were observed (P-values: < 0.05 evaluated by t-test and more than 2–fold change). (b,c) Heat maps showing differentially expressed genes that were categorized as highly expressed genes (>10 TMM values). Upregulated genes in NGO (b) and in FGO (c). Top Gene Ontology (GO) terms are shown in the heat map. RNA-Seq profiles indicated representative genes specific to NGO or FGO. (d) Expression state of representative transcription factors and epigenomic modifiers in NGO or FGO. (e,f) Chromosome distribution of upregulated genes in NGO (e) and FGO (f). Asterisks indicate significant differences by Fisher’s exacts test. *P < 0.01, **P < 0.002, ***P < 4.5e-5
