Table 4 Age-adjusted Hazard Ratios (HR) and 95% Confidence Intervals (CI) for Colorectal Cancer in Relation to SNPs in Genes in the Insulin-like Growth Factor Pathway in Men and Women in the Netherlands Cohort Study (1986–2002).

From: Genetic Variants in the Insulin-like Growth Factor Pathway and Colorectal Cancer Risk in the Netherlands Cohort Study

 

Colorectal cancer

Men

Women

PY

N cases

HR

(95% CI)

PY

N cases

HR

(95% CI)

IGF1

rs1520220

 CC

15,286

895

1

reference

15,700

603

1

reference

 CG

6,178

414

1.15

(0.97, 1.35)

7,207

277

1.00

(0.83, 1.19)

 GG

704

54

1.37

(0.92, 2.05)

765

31

1.03

(0.65, 1.63)

 P-trend

  

0.04

  

0.98

rs5742678

 CC

12,877

745

1

reference

13,025

497

1

reference

 GC

7,912

519

1.14

(0.98, 1.34)

9,086

355

1.01

(0.85, 1.20)

 GG

1,379

98

1.25

(0.92, 1.69)

1,561

59

0.98

(0.69, 1.37)

 P-trend

  

0.05

  

0.97

rs5742694

 TT

13,469

778

1

reference

13,695

518

1

reference

 GT

7,462

487

1.13

(0.97, 1.33)

8,568

341

1.03

(0.86, 1.22)

 GG

1,237

96

1.38

(1.01, 1.88)

1,410

51

0.96

(0.67, 1.37)

 P-trend

  

0.02

  

0.95

rs10735380

 AA

12,365

724

1

reference

12,983

469

1

reference

 AG

8,346

533

1.10

(0.94, 1.28)

9,052

378

1.14

(0.96, 1.35)

 GG

1,456

105

1.25

(0.93, 1.67)

1,638

64

1.06

(0.76, 1.47)

 P-trend

  

0.09

  

0.26

IGFBP3

rs2854744

 AA

4,654

279

1

reference

4,778

193

1

reference

 CA

11,173

690

1.04

(0.85, 1.26)

11,750

446

0.93

(0.75, 1.15)

 CC

6,341

393

1.03

(0.83, 1.28)

7,128

270

0.96

(0.76, 1.22)

 P-trend

  

0.80

  

0.82

rs2132572

 GG

13,360

768

1

reference

13,901

518

1

reference

 GA

7,661

510

1.12

(0.96, 1.31)

8,476

343

1.07

(0.90, 1.27)

 AA

1,147

85

1.29

(0.93, 1.79)

1,295

50

1.06

(0.73, 1.54)

 P-trend

  

0.06

  

0.49

rs35440925

 CC

13,704

882

1

reference

14,615

579

1

reference

 CG

7,479

422

0.89

(0.76, 1.05)

8,113

294

0.92

(0.77, 1.10)

 GG

985

59

0.97

(0.67, 1.39)

944

37

1.02

(0.67, 1.57)

 P-trend

  

0.27

  

0.54

IRS1

rs1801278

 GG

19,004

1,155

1

reference

20,576

789

1

reference

 GA

3,017

203

1.11

(0.90, 1.37)

3,047

119

1.03

(0.80, 1.31)

 AA

147

5

0.60

(0.20, 1.77)

49

3

2.33

(0.47, 11.65)

 P-trend

  

0.58

  

0.66

IRS2

rs1805097

 AA

2,709

151

1

reference

3,018

111

1

reference

 GA

10,044

604

1.07

(0.84, 1.36)

10,621

405

1.01

(0.77, 1.32)

 GG

9,274

603

1.15

(0.90, 1.47)

9,985

392

1.07

(0.82, 1.40)

 P-trend

  

0.20

  

0.51

rs2289046

 GG

2,511

134

1

reference

2,838

109

1

reference

 GA

10,059

607

1.13

(0.88, 1.46)

10,676

398

0.94

(0.72, 1.23)

 AA

9,598

622

1.20

(0.93, 1.55)

10,158

404

1.03

(0.78, 1.34)

 P-trend

  

0.15

  

0.57

rs754204

 CC

5,876

336

1

reference

6,496

248

1

reference

 TC

11,128

694

1.08

(0.91, 1.30)

11,468

438

0.98

(0.81, 1.20)

 TT

4,754

326

1.17

(0.95, 1.45)

5,291

215

1.04

(0.82, 1.31)

 P-trend

  

0.14

  

0.78

rs4773082

 TT

6,560

357

1

reference

6,954

249

1

reference

 CT

10,190

623

1.11

(0.93, 1.33)

10,299

382

1.00

(0.82, 1.23)

 CC

3,813

243

1.12

(0.89, 1.41)

4,082

152

1.03

(0.80, 1.33)

 P-trend

  

0.27

  

0.81

GHRHR

rs4988496

 GG

19,743

1,204

1

reference

20,791

813

1

reference

 AG

2,346

153

1.05

(0.83, 1.33)

2,783

93

0.86

(0.66, 1.12)

 AA

63

4

1.02

(0.25, 4.10)

98

5

1.32

(0.40, 4.38)

 P-trend

  

0.72

  

0.39

PPARG

rs1801282

 GG

187

12

1

reference

389

12

1

reference

 GC

4,814

280

0.86

(0.38, 1.95)

4,916

194

1.26

(0.61, 2.58)

 CC

17,151

1,071

0.92

(0.41, 2.06)

18,363

705

1.21

(0.60, 2.44)

 P-trend

  

0.58

  

0.93

ADIPOQ

rs1501299

 AA

1,620

103

1

reference

1,710

51

1

reference

 CA

8,834

108

0.92

(0.68, 1.23)

8,779

366

1.39

(0.97, 1.98)

 CC

11,715

751

1.03

(0.77, 1.37)

13,184

493

1.26

(0.89, 1.79)

 P-trend

  

0.34

  

0.88

rs2241766

 TT

17,305

1,103

1

reference

18,368

729

1

reference

 GT

4,562

244

0.83

(0.69, 1.00)

4,849

164

0.85

(0.68, 1.05)

 GG

170

10

0.91

(0.38, 2.16)

358

16

1.10

(0.57, 2.12)

 P-trend

  

0.06

  

0.25

rs266729

 GG

1,329

93

1

reference

1,909

60

1

reference

 GC

8,742

545

0.90

(0.66, 1.23)

8,479

334

1.32

(0.94, 1.86)

 CC

12,098

724

0.84

(0.62, 1.15)

13,285

517

1.29

(0.93, 1.80)

 P-trend

  

0.22

  

0.36

rs1648707

 AA

9,974

597

1

reference

10,948

426

1

reference

 CA

10,041

616

1.03

(0.88, 1.21)

9,970

393

1.00

(0.84, 1.19)

 CC

2,153

150

1.19

(0.92, 1.53)

2,754

92

0.81

(0.62, 1.08)

 P-trend

  

0.25

  

0.27

rs182052

 GG

9,900

592

1

reference

10,891

424

1

reference

 GA

10,085

617

1.03

(0.88, 1.21)

9,966

393

1.00

(0.84, 1.19)

 AA

2,183

154

1.20

(0.93, 1.54)

2,816

94

0.82

(0.62, 1.08)

 P-trend

  

0.23

  

0.29

ADIPOR1

rs1342387

 AA

4,266

234

1

reference

4,555

195

1

reference

 GA

11,418

725

1.16

(0.95, 1.42)

12,350

447

0.86

(0.69, 1.06)

 GG

6,484

403

1.12

(0.90, 1.40)

6,751

267

0.94

(0.74, 1.20)

 P-trend

  

0.42

  

0.77

rs7539542

 CC

10,697

671

1

reference

11,152

469

1

reference

 CG

9,496

566

0.95

(0.82, 1.11)

10,282

361

0.84

(0.71, 1.00)

 GG

1,957

125

0.99

(0.76, 1.30)

2,130

81

0.95

(0.70, 1.29)

 P-trend

  

0.72

  

0.19

rs12733285

 CC

1,884

94

1

reference

1,610

80

1

reference

 CT

9,301

573

1.27

(0.95, 1.70)

9,981

370

0.76

(0.56, 1.05)

 TT

10,971

696

1.29

(0.97, 1.72)

12,008

459

0.80

(0.58, 1.09)

 P-trend

  

0.19

  

0.51

ADIPOR2

rs1044471

 CC

6,286

409

1

reference

6,861

240

1

reference

 CT

11,233

660

0.90

(0.76, 1.07)

11,637

473

1.12

(0.92, 1.36)

 TT

4,614

293

0.98

(0.79, 1.21)

5,141

197

1.08

(0.85, 1.37)

 P-trend

  

0.74

  

0.47

rs767870

 TT

14,593

923

1

reference

16,325

609

1

reference

 TC

6,917

403

0.91

(0.77, 1.07)

6,664

278

1.13

(0.94, 1.35)

 CC

659

37

0.87

(0.56, 1.36)

668

23

0.93

(0.56, 1.57)

 P-trend

  

0.22

  

0.36

  1. Abbreviations: ADIPOQ, adiponectin; ADIPOR1 and -2, adiponectin receptor 1 and 2; CI, confidence interval; GHRHR, growth hormone releasing hormone receptor; HR, hazard ratio; IGF1, insulin-like growth factor 1; IGFBP3, insulin-like growth factor binding protein 3; IRS1 and -2, insulin receptor substrate 1 and 2; N, number of; PPARG, peroxisome proliferator-activated receptor gamma; PY, person-years at risk.
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