Table 3 Total and stratified subgroup analysis for each OPN gene polymorphism site and cancer.
Variables | N a | Cases/Controls | Allele model | Recessive model | Homozygous model |
|---|---|---|---|---|---|
OR(95% CI) P b P c | OR(95% CI) P b P c | OR(95% CI) P b P c | |||
rs17524488(−156 GG/G) | |||||
Total | 7 | 2130/2644 | 0.85(0.72–1.01) 0.002 0.060 | 0.81(0.66–0.99) 0.028 0.043 | 0.76(0.55–1.06) 0.002 0.109 |
HWE | 5 | 1570/2084 | 0.86(0.68–1.09)0.000 0.211 | 0.76(0.47–1.23)0.000 0.260 | 0.84(0.63–1.13)0.010 0.255 |
HB | 3 | 1173/1210 | 1.01(0.78–1.31) 0.017 0.921 | 1.01(0.65–1.59) 0.009 0.949 | 1.06(0.67–1.70) 0.046 0.799 |
PB | 4 | 957/1434 | 0.75(0.67–0.85) 0.232 0.000 | 0.81(0.72–0.91) 0.558 0.000 | 0.84(0.77–0.91) 0.103 0.000 |
gastric cancer | 2 | 346/328 | 0.94(0.64–1.37) 0.085 0.733 | 0.89(0.46–1.74) 0.081 0.742 | 0.95(0.79–1.14) 0.178 0.591 |
rs11730582(−443T/C) | |||||
Total | 8 | 2241/2857 | 0.86(0.58–1.30) 0.000 0.477 | 0.92(0.55–1.53) 0.000 0.739 | 0.85(0.42–1.72) 0.000 0.653 |
HB | 4 | 1284/1423 | 1.18(0.69–2.01) 0.000 0.543 | 1.40(0.66–2.99) 0.000 0.383 | 1.51(0.53–4.30) 0.000 0.445 |
PB | 4 | 957/1434 | 0.63(0.39–1.01) 0.000 0.055 | 0.63(0.49–0.82) 0.903 0.000 | 0.46(0.35–0.62) 0.200 0.000 |
gastric cancer | 2 | 346/328 | 1.14(0.65–1.99) 0.016 0.653 | 1.25(0.34–4.69) 0.016 0.736 | 1.33(0.30–5.84) 0.009 0.709 |
rs9138 (C/A) | |||||
Total | 2 | 418/424 | 1.38(0.88–2.16) 0.047 0.159 | 1.62(1.02–2.57) 0.883 0.041 | 2.16(1.28–3.63) 0.565 0.004 |
