Figure 3 | Scientific Reports

Figure 3

From: Development of Novel Triazolo-Thiadiazoles from Heterogeneous “Green” Catalysis as Protein Tyrosine Phosphatase 1B Inhibitors

Figure 3

(A) In vitro anti-angiogenic activity of BPTT using HUVEC. In presence of VEGF, HUVECs form tubular structures on the Matrigel and in the presence of BPTT substantially decreased the continuity and number of HUVEC capillary-like structures. (B) Inhibitory activity of BPTT on rat-aortic ring formation by fibro-adipose tissue of Sprague-Dawley rats. The treatment of BPTT significantly inhibited VEGF-induced sprouting of microvessels. (C) In vitro anti-invasive activity of BPTT using HepG2 cells. In this assay system, we used CXCL12 as an inducer of invasion of HepG2 cells. The treatment with HepG2 cells reduced the motility of cells that could invade Matrigel. Data are the representatives of three independent experiments. *p < 0.05.

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