Table 1 Demographic and clinical characteristics of study subjects.

From: Circulating cell death biomarker: good candidates of prognostic indicator for patients with hepatitis B virus related acute-on-chronic liver failure

 

HC (n = 40)

CHB (n = 40)

ACLF (n = 54)

Total (n = 54)

SR (n = 22)

NSR (n = 32)

P*

Male n (%)

18 (45.00%)

28 (70.00%)

47 (87.04%)

21 (95.45%)

26 (81.25%)

0.127

Age (years)

31.88 ± 1.92

42.2 ± 1.82

45.54 ± 1.45

40.00 ± 2.29

49.34 ± 1.57

0.001

BMI (kg/m2)

21.90 ± 0.42

22.61 ± 0.47

24.01 ± 0.43

23.63 ± 0.57

24.28 ± 0.62

0.469

HBeAg positive n (%)

/

22 (55.00%)

22 (40.74%)

12 (54.54%)

10 (31.25%)

0.087

Cirrhotic n (%)

/

/

32 (59.26%)

11 (50.00%)

21 (65.63%)

0.251

ALT (IU/L)

12.73 ± 0.53

96.53 ± 16.75

222.09 ± 39.96

197.09 ± 67.44

239.28 ± 49.65

0.081

AST (IU/L)

17.68 ± 0.84

53.88 ± 7.13

214.19 ± 24.55

141.95 ± 19.51

263.84 ± 36.97

0.012

albumin (g/L)

43.63 ± 0.51

37.75 ± 5.45

28.76 ± 0.61

28.77 ± 1.08

28.75 ± 4.05

0.985

BPC ( × 109)

/

157.67 ± 9.78

84.28 ± 5.47

92.09 ± 9.62

78.91 ± 6.40

0.231

hemoglobin (g/L)

/

138.41 ± 2.53

112.04 ± 3.13

109.14 ± 4.97

114.03 ± 28.07

0.448

Log10HBV-DNA (IU/mL)

/

4.13 ± 0.26

4.50 ± 0.24

3.74 ± 1.42

5.02 ± 0.31

0.007

TB (μmol/L)

12.73 ± 0.82

37.40 ± 10.46

447.03 ± 24.68

368.13 ± 31.33

501.28 ± 32.67

0.007

Cr (μmol/L)

/

74.69 ± 8.45

98.11 ± 6.77

86.50 ± 5.23

106.09 ± 10.70

0.398

INR

/

/

2.09 ± 0.08

1.81 ± 0.07

2.27 ± 0.11

0.002

MELD score

/

/

28.09 ± 0.71

24.95 ± 0.67

30.25 ± 0.95

 < 0.001

MELD-NA score

/

/

32.77 ± 1.32

27.92 ± 1.27

36.11 ± 1.83

 < 0.001

CTP score

/

/

11.65 ± 0.24

10.74 ± 0.33

12.25 ± 0.28

0.001

  1. Data were presented as numbers (percentage) and mean ± SEM.
  2. Abbreviation: BPC, blood platelet counts; TB, total bilirubin; Cr, Creatinine; INR, international normalized ratio; HBeAg, hepatitis B e antigen.
  3. Mann-Whitney U test and independent-samples t-test for continuous factors and Pearson’s chi-square test for categorical factors were used as appropriate.
  4. *P values correspond to the comparison of the SR and NSR groups of HBV-ACLF patients.
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