Table 3 Univariate and multivariate analyses of the HBV-ACLF cohort.

From: Circulating cell death biomarker: good candidates of prognostic indicator for patients with hepatitis B virus related acute-on-chronic liver failure

 

Univariate analysis

Multivariate analysis#

P

HR

95%CI

P

HR

95%CI

Gender (male vs female)

0.283

0.614

0.252–1.495

   

Age (years)

0.005

1.048

1.014–1.083

   

BMI (kg/m2)

0.371

1.056

0.937–1.191

   

ALT (IU/L)

0.261

1.001

1.000–1.002

   

AST (IU/L)

<0.001

1.004

1.002–1.006

   

WBC (×109/L)

<0.001

1.109

1.059–1.161

   

hemoglobin (g/L)

0.140

1.012

0.996–1.028

   

albumin (g/L)

0.898

1.005

0.931–1.085

   

BPC (×109/L)

0.322

0.995

0.986–1.005

   

TB (μmol/L)

0.002

1.003

1.001–1.005

   

Cr (μmol/L)

0.053

1.007

1.000–1.014

   

INR

0.001

2.516

1.430–4.425

   

Sodium (mmol/L)

0.146

0.952

0.891–1.017

   

HBeAg positive (yes vs no)

0.035

0.446

0.211–0.946

   

Log10HBV-DNA (IU/mL)

0.002

1.336

1.108–1.612

   

M30-antigen (U/L)*

<0.001

3.864

2.408–6.200

0.044

2.027

1.683–2.371

M65-antigen (U/L)*

<0.001

4.910

2.662–9.057

0.039

2.431

2.008–2.854

HMGB1 (ng/mL)

0.464

1.013

0.978–1.049

   

MELD

<0.001

1.137

1.070–1.209

0.0016

1.118

1.083–1.153

CTPs

0.012

1.311

1.060–1.622

   
  1. Abbreviation: WBC, white blood cell, BPC, blood platelet counts; TB, total bilirubin; Cr, Creatinine; INR, international normalized ratio; HBeAg, hepatitis B e antigen.
  2. #Variables identified as P < 0.05 in univariate analyses were further analyzed in multivariate analysis.
  3. *Loge transformation.
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