Figure 6
From: RBM45 homo-oligomerization mediates association with ALS-linked proteins and stress granules
Schematic overview of RBM45 domains structure and protein-protein interactions.
(a) Domain structure of RBM45 with the newly identified HOA (homo-oligomer assembly) domain highlighted in blue and the NLS in red. (b) A working model for RBM45 homo-oligomerization and distribution in the cell. RBM45 monomers assemble into a ring-shape pentamer which may dimerize to form a decamer. The RBM45 homo-oligomer acts as a scaffold to associate with TDP-43 mediated by RNA in the nucleus or cytoplasm. Accumulation of RBM45 in the cytoplasm leads to stress granule inclusion together with TIAR and TDP-43.
