Figure 3
NEUROD6-related SNPs are associated with AD specifically in APOE4+ female patients.
(a) Plot showing a “cone” of disease associated SNPs around NEUROD6 in APOE4+ female patients, but not in APOE4+ male, APOE4- female, or APOE4- male patients. Top AD-associated SNPs related to NEUROD6 in APOE4+ female patients in ADNI1 were: rs1917011 (p < 3.82e-5 in female APOE4+ patients, p < 0.692 in male APOE4+, p < 0.844 in female APOE4-), rs2159766 (p < 3.82e-5 in female APOE4+, p < 0.771 in male APOE4+, p < 0.624 in female APOE4-) and rs12701070 (p < 3.82e-5 in female APOE4+, p < 0.561 in male APOE4+, p < 0.624 in female APOE4-). (b) Propensity plots showing the disease risk (positive values) or protection (negative values) in APOE4+ female patients as a function of a patient’s status for each of three top NEUROD6 SNPs. (c) Plot showing disease associated SNP near NEUROD6 in APOE4+ female patients, but not in APOE4+ male, APOE4- female, or APOE4- male patients from the LOAD data set. This SNP was rs6972352 (p < 0.00049 in female APOE4+, p < 0.2247 in male APOE4+ and p < 0.010 in female APOE4-). (d) Propensity plots showing the disease risk (positive values) or protection (negative values) in APOE4+ female patients as a function of a patient’s status for each of three top NEUROD6 SNPs.
