Figure 1

Identification of down-regulated miR-144 in HPR and CR NSCLCs.

(A) MiRNA expression profiles of tumour and adjacent normal lung tissues from 10 NSCLCs. Left, data were organized according to the expression levels of individual miRNAs. Right, heat map showing 7 representative miRNAs down-regulated in the tumour samples. (B) Differentially expressed miRNAs in HPR compared to CR NSCLCs. (C) The expression of miR-3195, −3656, −1915-3p and −451a in tumour samples and their paired normal lung tissues. The numbers of patients tested are shown in parentheses. (D, E) The expression of miR-144 in tumour samples and their counterpart normal lung tissues (D). MiR-144 expression was frequently decreased in cancer tissues (E). A log2 fold change greater than +2 or less than −2 was considered to be a significant up-regulation or down-regulation, respectively. (F) The expression of miR-144 in tumour samples and paired normal lung tissues from HPR and CR NSCLCs.