Figure 4
Inhibition of the hematogenous dissemination in lung in a mouse B16F10 melanoma model.
C57BL/6J mice were immunized with pFAP-transfected, pVector-transfected, or non-transfected B16F10 cells or n.s. and 5 × 105 B16F10 cells were injected into the tail vein at day 7 after the third immunization. The lungs were weighed and assessed for the presence of hematogenous dissemination when the control mice became moribund. (a) Representative images of mouse lungs. (b) Average lung weights. The lungs from pFAP-B16F10 cell-immunized mice were significantly smaller than those from mice immunized with pVector-B16F10 or non-transfected B16F10 cells (P < 0.01) or treated with n.s. (P < 0.001). Points, mean (n = 10).
