Figure 5

Decreased expression of C1q mRNA expression in macrophages by treatment with irbesartan both in vivo and in vitro. (a) The mRNA levels of C1qa in CD11b + and F4/80 + macrophages sorted from TA muscles of mice treated with irbesartan or vehicle at 6 d after cryoinjury (n = 6, in each group). Data are shown as fold induction over vehicle (mean ± SEM). *P < 0.05. (b) The mRNA levels of Tnf and Nos2 in Raw264.7 cells after stimulation with LPS or vehicle (n = 9, in each group). Data are shown as fold induction over vehicle (mean ± SEM). *P < 0.05. (c) The mRNA levels of Mrc1 and Retnla in Raw264.7 cells after stimulation with IL-4 or vehicle (n = 9, in each group). Data are shown as fold induction over vehicle (mean ± SEM). *P < 0.05. (d) The mRNA levels of C1qa in LPS-stimulated Raw264.7 cells after treatment with irbesartan or vehicle (n = 9, in each group). Data are shown as fold induction over vehicle (mean ± SEM). **P < 0.01. (e) The mRNA levels of C1qa in IL-4-stimulated Raw264.7 cells after treatment with irbesartan or vehicle (n = 9, in each group). Data are shown as fold induction over vehicle (mean ± SEM). **P < 0.01.