Figure 5 | Scientific Reports

Figure 5

From: Expression of IL-37 contributes to the immunosuppressive property of human CD4+CD25+ regulatory T cells

Figure 5

Effects of IL-37 on CTLA-4 and FOXP3 expression in CD4+CD25+Tregs.

Normal condition means that after being isolated from human PBMCs, Tregs were cultured with Treg expander for 24 h; si-RNA-IL-37 condition means that silenced Tregs were cultured with Treg expander for 24 h. Expressions of CTLA-4 and FOXP3 were determined by flow cytometry (A,B). Results of independent experiments were shown as the mean ± SD. Statistically significant difference when compared with normal controls, P < 0.05 (C).

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