Figure 1 | Scientific Reports

Figure 1

From: Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response

Figure 1

Proposed model representing the B cell subtypes involved in the development of the AR.

In first contact, the allergen is presented to naïve B-cells; these activate and begin somatic hypermutation and class-switch recombination. Some of them become short-lived plasma-cells able to secrete low-affinity IgE as the first step of immunological protection. Another subset of activated B-cells becomes Memory B-cells. In successive contact with the allergen the memory B-cells differentiate into plasmablast that are able to secrete spIgE and proliferate, differentiating into: Long-lived plasma-cells, that preferentially recirculate to Bone Marrow and Inflammatory plasma-cells, that are recruited to the peripheral tissues and act as the real effector cells with the secretion of spIgE. This proposed model is based on our current knowledge of IgG responses.

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