Figure 6
Evolution of Ig serum levels and IgG4 secreting cells in CG, RP and NRP.
Ig levels in the different time points of the study were measured at the same time at the end of the first year of treatment. (A) Evolution of Total IgE (Ku/L). (B) Ratio between spIgE and spIgG4 in the three groups of patients represented as means and SD showing a significant decrease in RP from the first month of treatment. (C) Evolution of the percentage of IgG4 secreting cells determined by ELISpot and IgG4 serum levels determined by ImmunoCAP-FEIA in (C1) Controls, (C2) NRP and (C3) RP, where an increase of both parameters from the first month of AIT was observed. Statistical Wilcoxon and Mann-Whitney U tests were performed. The Bonferroni correction was applied for comparison of three groups and five different time points.
