Table 1 List of genes that are most upregulated during growth with AMS.

From: A novel siderophore system is essential for the growth of Pseudomonas aeruginosa in airway mucus

PA number

Gene

Fold changea

Target Description

PA3446

56.63

conserved hypothetical protein

PA3600

49.03

conserved hypothetical protein/Translation, post-translational modification

PA0284

36.28

hypothetical protein

PA4063

35.15

hypothetical protein

PA3601

24.27

conserved hypothetical protein/Translation, post-translational modification

PA2359

21.93

probable transcriptional regulator

PA3450

21.63

probable antioxidant protein/adaptation, protection

PA4570

19.36

hypothetical protein

PA4471

18.45

hypothetical protein

PA2161

16.99

hypothetical protein

PA0802

16.82

hypothetical protein/Membrane proteins

PA5536

dksA2

15.69

DnaK suppressor protein

PA2062

15.52

probable pyridoxal-phosphate dependent enzyme/Putative enzymes

PA1911

femR

13.79

sigma factor regulator

PA2033

11.83

hypothetical protein

PA1905

phzG2

11.29

probable pyridoxamine 5′-phosphate oxidase/Secreted Factors

PA4230

pchB

10.98

salicylate biosynthesis protein PchB/Transport of small molecules; Secreted Factors

PA1373

fabF2

10.86

3-oxoacyl-acyl carrier protein synthase II/Fatty acid and phospholipid metabolism

PA4103

10.61

hypothetical protein

PA4224

pchG

10.61

pyochelin biosynthetic protein PchG

PA2570

lecA

10.15

PA-I galactophilic lectin/Adaptation, protection; Motility & Attachment Cell wall

PA2786

9.98

hypothetical protein

PA1300

9.66

probable sigma-70 factor, ECF subfamily/Transcriptional regulators

PA3381

9.55

probable transcriptional regulator/Transcriptional regulators

PA0993

cupC2

9.36

chaperone CupC2/probable pili assembly chaperone/Motility & Attachment

PA4033

mucE

9.01

hypothetical protein

PA4837

8.95

probable outer membrane protein precursor/Membrane proteins

PA4516

8.93

hypothetical protein

PA4834

8.33

hypothetical protein/Membrane proteins

PA4226

pchE

8.27

dihydroaeruginoic acid synthetase/Transport of small molecules; Secreted Factors

PA0790

8.05

hypothetical protein/Membrane proteins

PA3126

ibpA

7.92

heat-shock protein LbpA/Chaperones & heat shock proteins

PA1312

7.84

probable transcriptional regulator/Transcriptional regulators

PA2426

pvdS

7.76

sigma factor PvdS/Transcriptional regulators

PA4225

pchF

7.23

pyochelin synthetase/Transport of small molecules; Secreted Factors

  1. aFold change was based on expression level in PAO1 incubated in PBS for the same period of time.