Figure 3 | Scientific Reports

Figure 3

From: Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice

Figure 3

Pharmacological inhibition of spinal glial cells reduced joint nociception in AIA model.

Immunized mice were challenge i.a. with 100 μg per joint of mBSA or vehicle (veh—sterile saline). Animals were pre treated with (A) fluorocitrate (fluoro—1 nmol/5 μL) or (B) minocycline (mino—1,5 μmol/5 μL) intrathecally (i.t.) 30 minutes before challenge and weight distribution was evaluated 3, 6, 9 and 24 hours after challenge. Animals were post-treated i.t. with fluoro (1 nmol) or mino (1,5 μmol) 6 (C) or 24 (D) hours after challenge. Weight distribution was evaluated 2, 6 and 24 hours after drugs administration. Data are means ± S.E.M. (n = 5). #P < 0.05 compared with vehicle group and *P < 0.05 compared with vehicle/mBSA group. BL (baseline).

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