Figure 4 | Scientific Reports

Figure 4

From: Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice

Figure 4

Glial cells activation markers increased in the spinal cord during AIA.

Immunized mice were challenge i.a. with 100 μg per joint of mBSA or vehicle (veh-sterile saline). Spinal cord samples were collected 3, 6, 9 and 24 hours after challenge, processed and analyzed by qRT-PCR or Western Blotting (WB). (A) GFAP mRNA and protein expression in spinal cord were evaluated (B) Iba1 (Aif1 gene) mRNA and protein expression in spinal cord were evaluated. Data are means ± SEM (n = 4 to Western Blotting and 7 to PCR). *P < 0.05 compared with vehicle.

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