Figure 4

Robust performance of MeSiC.

(A) We compared concordances (left panel) and PCCs (right panel) between 5 mC levels and predictions of MLR (green), SVM (yellow) and RFR (dark blue) models. The concordances and PCCs between 5 mC levels and predictions of RFR models (B) with the percentage of MeDIP-seq reads decreasing from 100% to 10% in decrements of 10% and (C) with the percentage of noise increasing from 0 to 100% in increments of 5%. (D) The distributions of MeSiC predictions at CpG sites where MeDIP-seq coverages were 0 while the methylation status were either fully methylated (5 mC levels = 1) or fully unmethylated (5 mC levels = 0) and *** indicates p-value < 2.2e⁻¹⁶.