Figure 4 | Scientific Reports

Figure 4

From: Direct chemotherapeutic dual drug delivery through intra-articular injection for synergistic enhancement of rheumatoid arthritis treatment

Figure 4

Feet photographs of RA rats after intra-articular injection of Dex-M, Met-HA, or Met-HA/Dex-M at 1–6 weeks (Scale bars = 15 mm).

*In accordance with one referee’s suggestion, the experiment for intra-articular injection of free Met was performed at 1, 3, 4 weeks. The feet images showed severe edema and erythema at 1, 3, 4 weeks (Supplementary information), indicating that intra-articular injection of free drug failed to produce significant repair. Thus this result demonstrates that the injectable formulations in this work can improve the therapeutic effectiveness.

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