Figure 3
From: Molecular Magnetic Resonance Imaging of Tumor Response to Therapy
Imaging the therapeutic response to metronomic chemotherapy in HeLa tumor-bearing mice.
(a) Representative MR images of untreated (left) and treated mice (center) receiving C-SNAM and treated mice receiving NC-ctrl (right) pre-contrast (top) and 50 min post-contrast (bottom). Tumor is indicated by white arrow, hot spot is indicated by yellow arrowhead. Water and 0.5 mM Dotarem phantoms are shown on bottom left and right, respectively, of each image. (b) Representative voxel histograms for untreated (black) and treated (blue) mice receiving C-SNAM and treated mice receiving NC-ctrl (red). Histograms are shown 50 min post-contrast (solid bars) and 110 min post-contrast (open bars). (c) The percent signal enhancement (%SE) for the hotspot signal enhancement (mean signal within the top quartile of the enhancement histogram) is plotted over time for untreated (black) and treated (blue) mice receiving C-SNAM and treated mice receiving NC-ctrl (red). Values are mean ± s.d., *p < 0.05 (general linear model repeated measures) and n = 4 per group.
