Figure 3
Voltage-dependent properties of KV and NaV channels expressed in X. laevis (•) and X. borealis (
) oocytes.
(a) Current-voltage relationship showing activation of KV10.1 channels (n = 12). (b) KV11.1 tail current plotted as a function of voltage to show activation properties (n = 9–12). The normalised deduced conductance (G)-voltage relationships for (c) NaV1.2, (d) NaV1.5 and (e) NaV1.7 (n = 12–17). (f) The effect of 300 nM ProTx-I on current evoked by a depolarisation to –15 mV from a holding potential of −80 mV (n = 8–9). There is no evidence of a difference between the two species (unpaired t-test, P > 0.05). Error bars indicate 95% confidence intervals.
